Among the 16,000 students who earn medical degrees in the United States every year, few of them have been sufficiently trained to address the health needs of the world’s most vulnerable populations. Helping these communities involves confronting cultural differences and language barriers, working in politically sensitive environments, and lacking access to technology and basic supplies.We train U.S. medical students, public health students, and residents to face these significant challenges and develop sustainable strategies for struggling communities. Working in New York City and directly in the field, students and residents learn hands on how to empower the medically disenfranchised and improve the lives of families around the world.Long-term and sustainable improvement in health requires establishing and strengthening local medical education. In many developing countries, the majority of locally trained healthcare professionals leave their home country once their training is complete. In some countries, poverty and a lack of infrastructure means that healthcare professionals cannot be adequately trained at all. Mount Sinai’s Global Health Center works to change this paradigm by training local health workers in developing countries so that communities can care for themselves.